Coombs Test in Chennai starting only @ Rs. 499

Coombs Test in Chennai

The coomb test, also widely referred to as antiglobulin test is used to detect the presence of antibodies that are attached to the surface of the red blood cells. Because of the presence of these antibodies your immune system might be killing or destroying the red blood cells which might be the cause for disorders like Hemolytic anaemia. The main purpose of this test is to identify these antibodies and diagnose them to prevent disorders like Autoimmune Hemolytic Anaemia (AIHA). There are two types of test involved in this process: Direct antiglobulin test (DAT) and Indirect antiglobulin test (IAT).

Direct Antiglobulin Test (DAT): Detects antibodies already bound to the patient’s red blood cells. It is used to diagnose autoimmune Hemolytic anaemia, transfusion reactions, and Hemolytic disease of the newborn.

Indirect Antiglobulin Test (IAT): Detects antibodies in the patient’s serum that are capable of binding to donor red blood cells. It is used for antibody screening and identification, especially in blood banking and compatibility testing.

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Symptoms

Abnormal paleness or lack of colour of the skin.
Yellowish skin, eyes, and mouth (jaundice)
Dark-colored urine.
Fever.
Weakness.
Dizziness.
Confusion.
Can’t handle physical activity.

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What conditions require a Coombs test?

One of the cases is when you fall sick after a blood transfusion. The donor’s blood might not be a match for you. The body attacks and destroys the other blood cells even though they are to help your body and this causes Anaemia symptoms. The destruction of blood cells is at a higher rate than the generation of new blood cells.
If a newborn child is suffering from jaundice, then most likely a Direct Coombs test is performed to check for any possible foreign antibodies attached to the red blood cells. This could be caused by the incompatibility of blood groups inherited by the newborn from its parents.
It is done in a pregnant mother or child where the mother has a rhesus-negative blood group and the child has a rhesus-positive blood group. Rhesus protein is a cell membrane protein on the RBC.
To find out conditions such as autoimmune haemolytic anaemia.
To avoid complications in the future, seek a Coombs test as soon as you find the mentioned symptoms. A Coombs Test can detect a range of illnesses like haemolytic anaemia, Jaundice, and low red blood cell (RBCS) count.

Procedure for Coombs Test:

Direct Coombs Test (DCT):
Blood sample collection.
Separation and washing of red blood cells.
Addition of Coombs reagent.
Observation of agglutination.
Indirect Coombs Test (ICT):
Blood sample collection.
Separation of serum from blood.
Mixing serum with test red blood cells.
Incubation of the mixture.
Washing of red blood cells.
Addition of Coombs reagent.
Observation of agglutination.

Key problems that can be determined by doing the Coombs Test

Autoimmune Hemolytic Anemia (AIHA):
Role: Essential for diagnosing AIHA, where antibodies mistakenly attack RBCs, leading to anemia.
Test Type: Direct Coombs Test (DCT) identifies antibodies bound to RBCs.
Hemolytic Disease of the Newborn (HDN):
Role: Screens for maternal antibodies against fetal RBCs, which can cause severe jaundice and anemia in newborns.
Test Type: Indirect Coombs Test (ICT) detects maternal antibodies in blood serum.
Blood Transfusion Compatibility:
Role: Determines compatibility between donor and recipient blood to prevent transfusion reactions.
Test Type: ICT identifies antibodies in recipient plasma that could react with transfused RBCs.
Evaluation of Drug-Induced Hemolytic Anemia:
Role: Identifies antibodies triggered by drugs that attack RBCs, causing anemia.
Test Type: DCT detects antibodies attached to RBCs.
RBC Autoantibodies in Systemic Lupus Erythematosus (SLE) and Other Autoimmune Diseases:
Role: Detects autoantibodies against RBCs, contributing to anemia in autoimmune conditions.
Test Type: DCT identifies antibodies on the patient’s RBCs.
Detection of Alloimmune Disorders:
Role: Screens for antibodies that develop after exposure to foreign RBC antigens, such as during multiple transfusions or transplants.
Test Type: Both DCT and ICT are used depending on clinical context.
Diagnosis of Paroxysmal Cold Hemoglobinuria (PCH):
Role: Identifies cold-reactive antibodies that cause transient RBC destruction, often triggered by cold exposure.
Test Type: DCT detects IgG antibodies on RBCs.
Evaluation of Hemolytic Anemias of Unknown Origin:
Role: Assists in identifying the underlying cause of hemolytic anemia when other tests are inconclusive.
Test Type: DCT helps confirm autoimmune etiology.
Monitoring Response to Treatment in AIHA and HDN:
Role: Tracks changes in antibody levels and RBC destruction post-treatment.
Test Type: Sequential Coombs tests (DCT and ICT) are used to assess treatment efficacy.
Prevention and Management in Pregnant Women with Rh Incompatibility:
Role: Screens Rh-negative mothers for antibodies against Rh-positive fetal RBCs to prevent HDN.
Test Type: ICT identifies antibodies in maternal serum.

Why Choose Medifyhome for a Coombs Test?

The greatest option available to you for the Coombs test is Medifyhome. We recognize that scheduling a test in the middle of your hectic schedule in a lab, hospital, or diagnostic centre may not be very convenient, which is why Medifyhome offers at-home service. We offer the much-needed assistance at a very affordable cost with excellent service. It assists you in receiving the right care, medication, and testing as quickly as feasible. With the help of our specialised professionals we provide excellent outcomes and meet quality medical standards with best equipped tools and equipment required.

FAQs

What is the main focus of the Coombs test?

To detect the antibodies which destroy the red blood cells and diagnose with the right treatment method.

Does the coombs test require the patient to be fasting before getting tested?

No you are not required to fast before getting tested for Coombs.

What kinds of tests are done in the Coomb test?

There are two tests involved in this process DAT(direct antiglobulin test) and IAT(indirect antiglobulin test).

Who is required to take the Coomb test?

People experiencing the anaemia symptoms, transfusion reactions, pregnant women at the risk of Rh incompatibility, and newborns with jaundice should get this test done.